Tamm-Horsfall ELISA Specifications
Range of Assay: 9.375 – 150 ng/mL
Sensitivity: <5.50 ng/mL
Length of Assay: 2 hours 40 min
Sample Size: 50 uL
Precision: < 12.2 %CV for intra- and inter-assay precision
Cross-Reactivity: Human and canine urine samples
Tamm-Horsfall protein (THP, also known as uromodulin) is the most abundant protein found in the urine of mammals. THP is 616 amino acids in length with a molecular weight of 80 kDa, and is synthesized in the thick ascending loop of Henle. While the specific function of THP is unknown, it appears to have a role in the regulation of salt and water excretion by the kidney. Soluble THP has been found to help protect against urinary tract infections of E. coli and P. mirabilis by inhibiting the binding of the bacteria to the epithelial cells of the urinary tract. In addition, it has been suggested that THP may help prevent renal stone formation. Defects in THP are associated with human diseases such as familial juvenile hyperuricemic nephropathy (FJHN) and medullary cystic kidney disease.
